Amatuximab
產品活性：Amatuximab(MORab-009)isachimeric,humanizedIgG1/kMAbthattargetsthecellsurfacemesothelin(MSLN).Mesothelinisaglycosylphosphatidylinositol(GPI)-anchoredmembraneglycoprotein,whichispresentinarestrictedsetofnormaladulttissuessuchasthemesothelium.
研究領域：Immunology/Inflammation
作用靶點：Mesothelin
InVitro:Amatuximab(MORAb-009)isamouse- ,amatuximabelicitsantibody-dependentcellularcytotoxicity(ADCC)againstmesothelinexpressingtumorcelllinesandinhibitsheterotypiccelladhesionofmesothelin-positivetumorcellstoCA125-expressingtumorcells.
InVivo:Intumorxenograftstudies,combinationtreatmentwithamatuximabpluschemotherapyledtoagreaterreductioninthegrowthofmesothelin-expressingtumorsthaneitherAmatuximaborchemotherapyalone.
Amatuximab
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